Do Anti-Epileptic Drugs Increase High Risk Comorbidity Amongst Patients With Neuro-Autoimmune Disease?

Objective To investigate the effects of anti-epileptic drugs (AED) on overall burden disease in patients with neuro-autoimmune (NAD). Background AEDs have shown to provide benefits against neurological damage various illnesses. However, extent role neuroprotection and prevention additional comorbidity NAD has not been completely characterized. Design/Methods A retrospective analysis 34464 hospitalized at a tertiary care center major metropolitan area was conducted. 3997 were AED medications, while 30467 taking any (nAED). 190 had diagnosis. Patients classified according use or nAED (aAED anAED). The outcomes compared included prevalence complications defined as either seizure, blurry vision, delirium, altered mental status, encephalopathy, length stay, ICU admission, comorbidity, death. Results There no significant difference between (0.75%, 0.52%, p > 0.05). Among aAED anAED, there stay (8.7, 7.8, 0.5), admission (26.7%, 12.5%, 0.05), comorbidities (56.7%, 52.5%, mortality (6.7%, 3.1%, 0.3). 36% 16.3% anAED high risk (p < 37% 10% among respectively 0.001). significantly higher encephalopathy 23% 3.8%, 0.0001). Conclusions These results suggest that may be associated an increase high-risk including NAD. Work is progress assess contribution primary diagnoses for which prescribed